Two of my hosts have had "Creators Update" shoved down their throats this week. Both started failing PrimeGrid GPU tasks immediately (Genefer and AP27, PPS-SV seems okay), having been "upgraded" by MS from Nvidia driver 376.53 to 382.05; manually installing 384.76 fixed that... (Same thing has happened on other "updates", so I wasn't too surprised by this one.)
One host continues to do WuProp and everything else fine. The other got stuck with a WuProp task uploaded but not reported. Hitting Update got a "Certificate Error". Reset, messed with certificates, rebooted, messed with firewall, all no go, still wouldn't report. Detached and tried to re-add project, could not get WuProp attached - "error 184" from BoincTasks, just a "try again later" doing it directly in BOINC Manager.
Tried to reattach using HTTP not HTTPS, and it worked fine. So somewhere there's a security issue...
Still have not solved similar problem with Collatz, where uploads are failing with "transient HTTP error". May try the non-S fix on that as well, just hate to lose the work. Sigh.